ECTS - University of Pisa
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INTRODUCTION TO MEDICINAL CHEMISTRY
GAETANO ANGELICI
Academic year2020/21
CourseCHEMISTRY
Code338CC
Credits3
PeriodSemester 1
LanguageItalian

ModulesAreaTypeHoursTeacher(s)
INTRODUZIONE ALLA CHIMICA MEDICINALECHIM/06LEZIONI24
GAETANO ANGELICI unimap
Syllabus not available in selected language
Learning outcomes
Knowledge

Introduction to Medicinal Chemistry will give to the students an overview of the issues and methods related with the synthesis and screening of new biological active molecules. Drug Design, Combinatorial approaches and Bioconjugation methods will be discussed from an organic chemistry point of view.
Assessment criteria of knowledge

Current research-related issues will be proposed to the students, to discuss possible solutions.
Skills

At the end of the course:

  • the students will be able to propose mimetics and analogs of natural molecules and biological active compounds
  • the students will be able to propose  synthetic methods of designed drugs
  • the students will learn the most recent advances in medicinal chemistry
Assessment criteria of skills

Current research-related issues will be proposed to the students, to discuss possible solutions.
Behaviors

At this point of their career, students should already possess all the soft skills they will need in the future, like managing their time, collaborate with their collegues and discuss their ideas. This course could be an opportunity to train those skills.
Assessment criteria of behaviors
  • Current research articles on Medicinal Chemistry will be given to small groups of students, which will critically present this work in class.
Prerequisites

Good knowledge of Organic Chemistry are required, particularly regarding, synthetic methods, reactions mechanisms, and stereochemistry.
Teaching methods
  • The course consists of direct lectures, but open debate is appreciated
  • PowerPoint presentations (in English) are used for the lessons
  • Meetings can be fixed directly e-mailing the teacher
Syllabus
  • Introduction to Medicinal Chemistry
  • Strategies in the search for new lead compounds
  • Systematic Screening
  • Isosteric Replacements and analogs synthesis
  • Structure – Activity relation
  • Bioconjugation methods
  • Biomimetics in Medicinal Chemistry
  • Combinatorial methods and rational design
Bibliography
  • Slides and notes of the lectures
  • Literature cited during lecture (all references will be given)
  • The Practice of Medicinal Chemistry (C. G. Wermuth et al, Elsevier)
  • The Organic Chemistry of Drug Design and Drug Action (Silverman and Holladay, Elsevier)
  • Chemistry of Bioconjugates, (Narain, Wiley)
Non-attending students info
  • An oral examination will be used as assessment method
  • the oral examination is normally 30-40 minutes long
  • the examination consists of questions concerning the course
  • candidates will be initially asked to propose design and synthesis of analogs of given molecules, as a starting point for exam questions
  • At the end of the examination, the teacher will assign a score (from 18/18 to a max of 30/30 cum laude) reflecting student's degree of preparation.

 
Additional web pages

http://www.sosandpepsy.org/
Updated: 04/08/2020 16:44