ECTS - University of Pisa
During this course students will have a deeper cognition on the metabolic pathways, on metabolic integration and on the specific biochemical aspects of the function of different organs. This will lead to a better comprehension of the molecular bases of diseases linked to an alteration of cellular metabolic pathways and proteins function.
The student must be able to demonstrate his/her knowledge of the course material and be able to discuss the reading matter thoughtfully and with propriety of expression
The student will be able to describe certain metabolic arrangements in cells and tissues, in different physiological and pathological conditions.
During the exam, students must be albe to demonstrate his/her knowledge of the course material and basic discipline (biochemistry and general physiology)
The student will be able to understand the effectiveness of the cell metabolism and the molecular mechanisms of pathogenesis
The student must be able to demonstrate his/her knowledge of the course material and be able to discuss the reading matter thoughtfully and with propriety of expression
The essential knowledge is general biochemistry and physiology, other useful knowledge are about organic chemistry and molecular biology.
Delivery: face to face
Learning activities:
Teaching methods:
Oxidative stress and cell systems involved in the defence from oxidative stress. Alterations of metabolic pathways in cancer. Metabolic pathways implicated in resistance to chemotherapy. Cellular mechanisms controlling protein folding. Protein misfolding and diseases. Lipid metabolism disorders. Purines and pyrimidines functions and metabolism. Disorders linked to alteration of purines and pyrimidines metabolism. Proteolytic mechanisms in cells. Proteolytic signaling in diseases. Covalent modification of proteins in the modulation of metabolic pathways.
Any good and recent test of biochemistry, presentations and scientific articles are available on the Moodle platform .
The exam is oral, the student will be asked to answer to 2-3 questions, in order to ascertain the knowledge of the items of the course.
