EU directives and national regulatory system for the quality and safety of herbal drugs and derivatives. Official definitions of herbal drug products and quality control. WHO guidelines on the quality control of herbal drugs and derivatives. Quality Assicurance and ISO normation for the production of plant extracts and essential oils. Supply and documentation of raw materials: certificate of analysis, technical and safety sheets. Pharmacopoeia and WHO guidelines for sampling and trasformation of herbal drugs and derivatives. Validation of analytical methods and ISO 17025. Official procedures and validated methods for the quality control of raw plant material, extracts, and essential oils.