The aim of the course is the acquisition by students of basic notions on imaging in medical diagnostic techniques, design and chemistry of contrast agents used for imaging. Description: Historical introduction on medical diagnostics. electromagnetic radiation and potential uses. X-rays and ionizing radiation. Alpha beta and gamma radiation. stable and radioactive isotopes. Properties of the particles and ionizing radiation. Medical Imaging and techniques. X-Ray tomography, MRI, and nuclear Ecography Imaging, introductory nods. The contrast and the introduction of contrast agent. Efficacy and safety. Radiography at Rx: the history, the technique, the machines of the iodinated contrast agents. Classifications, safety, efficacy, toxicity, solubility in water, chemical stability, chemical and physical properties of individual agents and their formulation and relationship with potential risks for the patient. Industrial preparations of certain iodinated contrast agents for X-Ray (Iopamidol). Preclinical toxicology tests, pharmacology, efficacy and safety used in the development of new diagnostic agents for imaging. Pharmacokinetic Concepts in the case of diagnostic agents and differences with those relating to drugs. The history, the theory and the equipment the development of techniques for X-Ray. Films of Ag bromide to direct digital radiography. Computed tomography. The technique, the image processing tools and the differences between X-ray and CT. Radiopharmaceuticals in nuclear medicine. Scintigraphy, techniques and agents in use (hints). Nuclear room. PET techniques. Theory, instrumentation, longer in use radionuclides. Production of Radionuclides, Cyclotrons, organization of a small workshop for the production of [18F] -FDG. Radiochemistry for the marking of molecules for use PET. Examples of functionalization of molecules for diagnostic use in PET. Using PET techniques for research purposes for the study of routes or the development of new drugs. SPECT technique, the machines. Molecular Imaging. Ultrasound and Ultrasound. The ultrasound theory, the ultrasound contrast generation. Doppler effect, the main of contrast agents for echography, production and their use. Magnetic resonance imaging. The theory of technique and its evolution to the diagnostic application. The excitation and relaxation techniques and the generation imaging effects of T1 and T2 in generating imaging opposed by different tissues. The instruments. as MRI contrast agents. Use of complex paramagnetic metal ions such as Gd (III), Mn (II) and Fe (III). Macromolecules, liposomes and micelles which incorporate complexes of Gd (III). Gd (III) complexes of I and II generation. pharmacological and toxicity issues related to the use of complexes. The research in Imaging compared to the old and new technologies.