ECTS - University of Pisa
Lo studente che completa con successo il corso avrà la capacità di comprendere i principi della Risonanza Magnetica Nucleare e la sua applicazione nell'uomo; sarà in grado di dimostrare la conoscenza dell'interazione radiazione elettromagnetica con i sistemi biologici e le tecniche di acquisizione delle immagini e di valutare gli effetti del rilassamento T1 e T2; sarà in grado di dimostrare la conoscenza dei rivelatori RF, sarà a conoscenza delle tecniche avanzate per le misurazioni quantitative non solo in esperimenti di laboratorio ma anche in vivo nell'uomo.
The student who successfully completes the course will have the ability to understand the principles of Nuclear Magnetic Resonance and its application in living systems; will be able to demonstrate the knowledge of electromagnetic radiation interaction with living systems and the techniques for acquiring images and to evaluate T1 and T2 relaxation effects; will be able to demonstrate knowledge of basic coils for signal detection; will be aware of the power and pitfalls of the advanced techniques for quantitative measurements.
Durante la prova orale lo studente dovrà dimostrare di conoscere il materiale del corso e di essere in grado di discuterne i principi e i metodi con terminologia appropriata. Lo studente sarà valutato sulla capacità di mettere in pratica ed eseguire, con consapevolezza critica, le attività illustrate o svolte durante il laboratorio.
During the oral exam the student must be able to demonstrate his/her knowledge of the course material and be able to discuss the principles and methods with appropriate terminology. The student will be assessed on his/her demonstrated ability to put into practice and to execute, with critical awareness, the activities illustrated or carried out during the laboratory.
Methods:
alla fine del corso lo studente sara' in grado di comprendere e misurare le features contenute in una immagine MRI e la diffreenza fra immaging di contasto e imaging quantitativo
at the end of the course the student will be able to understand which features are contained in an MRI image and the difference between contrast image and quantitative image
iterattiva durante le lezioni e le esercitazioni in laboratorio
iterative during lessons and laboratory
-elementi di interazione radiazione-materia
-elementi di elettromagnetismo (eq. di Maxwell, Legge di Faraday, Dipoli in campi em)
-metodi matemici per la fisica (i.e. Trasformata di Fourier)
-elements of radiation-matter
- interaction-elements of electromagnetism (Maxwell's equation, Faraday's law, dipoles in em fields)
- mathematical methods for physics (i.e. Fourier transform)
Lezione frontali in presenza
Attività didattiche:
partecipazione ai seminari
Frequenza obbligatoria
Metodi di insegnamento: Lezioni Seminari Laboratori
Delivery: face to face
Learning activities:
Attendance: Mandatory
Teaching methods:
Ed Esperienza 1 -c/o Stella Maris – IMAGO7 4 ore
Imaging quantitativo: Rilassometria (gold standard e implementazioni in-vivo). Concetto di model-based imaging. Artifact game show
Ed Esperienza 2 c/o Stella Maris – IMAGO7 4 ore
T2*-based techniques: T2* mapping, Quantitative Susceptibility Mapping and fMRI
Ed Esperienza 3 c/o Stella Maris – IMAGO7 4 ore
Caratterizzazione della degli scanner MR
Seminari:
-Structural and functional connectivity in the brain
-Measuring normality and pathology with big data: AI in medical imaging
Classical Bloch equations and basic quantum mechanical description Magnetization Interaction with RF; rotating frame Receiving and acquiring data Simple sequences to measure relaxation times; Gradient echo, spin echo and stimulated echo, inversion recovery Reconstruction imaging: slice selection, Phase and Frequency encoding (k space) Basic spectroscopy, and advanced imaging techniques Components of an MR scanner Interactions of MR fields with biological tissues.
Lab Experience 1 -c/o Stella Maris – IMAGO7 4 ore
quantitaive imaging: relaxation (gold standard and in-vivo experiment). Model-based imaging. Artifact game show
Lab Experience 2 c/o Stella Maris – IMAGO7 4 ore
T2*-based techniques: T2* mapping, Quantitative Susceptibility Mapping and fMRI
Lab Experience 3 c/o Stella Maris – IMAGO7 4 ore
Characterization of a MR scanner
Lectures:
-Structural and functional connectivity in the brain
-Measuring normality and pathology with big data: AI in medical imaging
-Structural and functional connectivity in the brain
-Measuring normality and pathology with big data: AI in medical imaging
[1] Magnetic Resonance Imaging: Physical Principles and Sequence Design. E.M Haacke, R W. Brown, M.R. Thompson, R. Venkatesan. Ed Wiley-Liss, 1999. Further bibliography [2] In Vivo NMR Spectroscopy: Principles and Techniques. Robin A. de Graaf. Ed. John Wiley & Sons, 2013. [3]Quantitative MRI of the Brain: Measuring Changes Caused by Disease. Paul Tofts. Ed. John Wiley and Sons, 2003. [4] Ultra High Field Magnetic Resonance Imaging. Pierre-Marie Robitaille, Lawrence Berliner. Ed. Springer, 2007.
Recommended reading: [1] Magnetic Resonance Imaging: Physical Principles and Sequence Design. E.M Haacke, R W. Brown, M.R. Thompson, R. Venkatesan. Ed Wiley-Liss, 1999. Further bibliography [2] In Vivo NMR Spectroscopy: Principles and Techniques. Robin A. de Graaf. Ed. John Wiley & Sons, 2013. [3]Quantitative MRI of the Brain: Measuring Changes Caused by Disease. Paul Tofts. Ed. John Wiley and Sons, 2003. [4] Ultra High Field Magnetic Resonance Imaging. Pierre-Marie Robitaille, Lawrence Berliner. Ed. Springer, 2007.
Metodi: Esame finale orale
Rapporto di laboratorio per la Parte del corso della Prof Andreozzi
Final oral exam
Laboratory report for Prof. Andreozzi part of the course
