Scheda programma d'esame
CHIMICA ANALITICA
ARMANDO ROSSELLO
Anno accademico2016/17
CdSCHIMICA E TECNOLOGIA FARMACEUTICHE
Codice233CC
CFU6
PeriodoPrimo semestre
LinguaItaliano

ModuliSettoreTipoOreDocente/i
CHIMICA ANALITICACHIM/01LEZIONI52
ELISA NUTI unimap
ARMANDO ROSSELLO unimap
Learning outcomes
Knowledge
This course aims to provide the necessary theoretical knowledge for training qualified student, particularly addressed to the quantitative determination of inorganic substances of pharmaceutical interest. Purpose, in addition, the course is the formation of a specific sensitivity to the professional work of chemical-pharmaceutical laboratory
Assessment criteria of knowledge
The student will be assessed on his/her demonstrated ability to discuss the main course contents. During the oral exam the student must be able to demonstrate his/her knowledge of the course material and be able to discuss the reading matter thoughtfully and with propriety of expression. - The student's ability to explain correctly the main topics presented during the course at the board will be assessed. In the written exam (2 hours, choice of 4/5 essay questions), the student must demonstrate his/her knowledge of the course material and to organise an effective and correctly written reply. - With the oral presentation, to be made to the teacher and the other students, the student must demonstrate the ability to approach a circumscribed research problem, and organise an effective exposition of the results. - The student must demonstrate the ability to put into practice and to execute, the activities illustrated or carried out under the guidance of the teacher during the course.

Methods:

  • Final oral exam
  • Final written exam
  • Oral report

Further information:
The written exam should be positively passed (min 18/30) and it should be before of the oral exam. The final evaluation will be made after the oral exam and it will be a specified weighting of final oral exam 50% and written exam (50%)

Teaching methods

Delivery: face to face

Learning activities:

  • attending lectures
  • preparation of oral/written report
  • individual study
  • group work
  • Bibliography search

Attendance: Mandatory

Teaching methods:

  • Lectures
  • Task-based learning/problem-based learning/inquiry-based learning
  • laboratory

Programma (contenuti dell'insegnamento)

Scopi della chimica analitica in campo farmaceutico. Cenni sulle buone pratiche di laboratorio. Misure di Massa e di Volume. Elaborazione dei dati. Analisi degli errori. Analisi di campioni. Scelta del metodo di analisi ed accuratezza ottenibile. Preparazione dei campioni per l’analisi. Campionamento (cenni). Cause di errore durante la decomposizione e dissoluzione dei campioni, metodi di decomposizione dei campioni (cenni). Eliminazione delle interferenze. Attività chimica ed equilibrio chimico. Reazioni Acido-Base. Sali ed idrolisi. Soluzioni tampone. Solubilità e precipitazione, Equilibri di solubilità ed effetti di pH.
Equilibri multipli in soluzione.

Principali tecniche Cromatografiche ed applicazioni utilizzabili nell’analitica Farmaceutica. principi generali. Cromatografia liquida su colonna classica, High Performance Liquid Chromatography (HPLC). Cromatografia a scambio ionico, Cromatografia su strato sottile (TLC), Gas cromatografia: descrizione, usi ed esempi di applicazioni. Introduzione alle tecniche spettroscopiche: radiazioni elettromagnetiche ed assorbimento. Legge di Lambert-Beer. Spettroscopia di assorbimento atomico (AAS). Spettroscopia UV-Visibile: teoria e applicazioni. Luminescenza, fluorescenza: teoria ed applicazioni.

 

Syllabus
Purposes of analytical chemistry in the pharmaceutical field. Good laboratory practices. Measurements of Mass and Volume. Data processing. Error analysis. Sample analysis. Analytical methods and accuracy obtainable. Analysis sample preparation . Sampling. Error causes during assays of of samples and methods of sample decomposition.Elimination of interferences. Chemical activity and chemical equilibrium. Acid-Base Reactions. Salts and hydrolysis. Buffer solutions. Solubility and precipitation, Solubility equilibria and effects of pH. Multiple equilibria in solution. Main Chromatographic techniques and applications. General principles of classic column liquid chromatography , High Performance Liquid Chromatography (HPLC). Ion exchange chromatography, thin layer chromatography (TLC), gas chromatography. Introduction to spectroscopic tecniques. Beer-Lambert law. Atomic absorption spectroscopy (AAS). UV-Visible, Luminescence,fluorescenc spectroscopy: theory and application.
Bibliografia e materiale didattico

- Hage D & Carr J D, Chimica Analitica e Analisi Quantitativa (Ed Piccin)
- Skoog - West - Holler – Crouch: Fondamenti di Chimica Analitica, (ed II/2005) Ed. EdiSES, Napoli.

- D.A. Skoog, J.J. Leary: Chimica Analitica Strumentale (Ed. Edises, Napoli).

Bibliography
- Skoog - West - Holler – Crouch: Fondamenti di Chimica Analitica, (ed II/2005) Ed. EdiSES, Napoli. - D.A. Skoog, J.J. Leary: Chimica Analitica Strumentale (Ed. Edises, Napoli).
Modalità d'esame

Prova scritta propedeutica alla
Prova orale

Work placement
Yes
Ultimo aggiornamento 14/11/2016 17:27