CdSBIOLOGIA MARINA
Codice511EE
CFU4
PeriodoSecondo semestre
LinguaItaliano
| Moduli | Settore/i | Tipo | Ore | Docente/i | |
| BIOCHEMISTRY OF ADAPTATION | BIO/10 | LEZIONI | 32 |
|
The student who successfully completes the course will be aware of the biochemical events involved in the adaptation of marine organisms in response to variation of their environment in terms of temperature, salinity, hypoxia, oxidative stress, presence of pollutants.
In the exam the student must be able to demonstrate his/her knowledge of the course material and basic discipline (biochemistry).
The student will be able to understand the biochemistry of adaptation and some of molecular defence against water pollution.
Students should have acquired the fundamental knowledge of the biochemical processes leading the adaptation of marine organism to environmental changes.
The student will be aware of the effect of pollution in marine environment on the survival of a number of species.
Students should have acquired the fundamental knowledge of the biochemical processes leading the effect of pollution in marine environment on the survival of a number of species.
Students should know basic biochemistry and the most relevant metabolic pathways, they should also have a general knowledge of general physiology.
Proteins structure. Protein folding. Enzymes: enzyme kinetics, kinetic parameters KM and kcat. The role of molecular chaperones in the de novo folding in the refolding after stress conditions (high temperature). The effect of cold temperature on proteins structure and functions. Anti-freeze proteins. Comparison of relevant features of proteins and enzymes from psycrophyl, mesophyl and thermophyl organisms. Adaptation to osmotic pressure: the role of osmolytes. Structure and functions of biological membranes. The effect of temperature on the composition of biological membranes. Myoglobin and hemoglobin: structure and function. The cooperativity of the oxygen binding to hemoglobin. The Bohr effect. The Root effect and its molecular basis. Oxidative stress and antioxidant defenses. Marine organisms adaption to hypoxia. Essential and not-essential metals. Metals toxicity. Pathways for metal detoxification. Muscle metabolism in diving marine organisms. Energetic metabolism in marine organisms.
Nelson and Cox. Lenhinger. Principles of Biochemistry.
Stryer. Biochemistry.
(this biography could be useful for obtain knowledges on protein structure and enzyme kinetis.)
During exam students are required to answer properly to questions demostrating the knowledge of topics covered in team classroom.